USC and partner institutions awarded $6 million children’s environmental health grant from NIH

Research to look at prenatal and early life environmental influences on lifetime health related to asthma and obesity

Staff Report

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LOS ANGELES – September 21, 2016 – Researchers at the Keck School of Medicine of USC have been awarded a 2 year $6 million grant, as the first phase of a large seven-year National Institutes of Health, Environmental Influences on Child Health Outcomes (ECHO) initiative involving more than 30 research entities. The USC based research team will investigate health issues related to asthma and obesity. Continue reading “USC and partner institutions awarded $6 million children’s environmental health grant from NIH”

Air pollution affects lung cancer survival time

Exposure to higher levels of air pollution shortens survival after lung cancer diagnosis

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Exposure to air pollution has many impacts across the lifespan and has now been linked to survival of patients after being diagnosed with lung cancer. Lung cancer has been the most commonly diagnosed cancer over the past several decades. Patterns of lung cancer incidence and mortality have been closely tied to exposure to tobacco smoke across time and place. There is also a growing body of evidence that shows that air pollution exposures are associated with lung cancer incidence and mortality but, since survival times after lung cancer diagnosis can be quite short, few studies have attempted to disentangle the two. In addition, the International agency for Research on Cancer (IARC) recently classified ambient air pollution as carcinogenic.

“We thought that if ambient air pollution is a carcinogen that can drive lung cancer development, then exposure to air pollution in patients already diagnosed with lung cancer could promote the progression of their disease through the same biological pathways.” said Sandrah Eckel, PhD, assistant professor of Preventive Medicine at the Keck School of Medicine and lead author of the research. Therefore, Dr. Eckel and colleagues at the Keck School of Medicine at the University of Southern California decided to more closely explore the question of whether lung cancer survival times might be affected by air pollution.

The research, published this month in Thorax, shows that the length of time that lung cancer patients live after diagnosis varies depending on their exposures to regional pollution. Researchers found that the median survival for people diagnosed with early stage lung cancers who lived in areas with high levels of regional pollution was approximately 3 years shorter than for people who lived in areas with lower levels of pollution. “We focused on California, since there are a wide range of air pollution levels here and one of the largest and longest running air quality monitoring networks and cancer registry system in the US,” said Eckel.

Dr. Eckel and her team of researchers looked at lung cancer data from over 350,000 patients in the California Cancer Registry who were diagnosed with lung cancer between 1988-2009. From the extensive and detailed dataset, the team assigned air pollution exposure levels based on the average exposure at the patient’s residence at diagnosis. The pollutants that were used included: nitrogen dioxide (NO2, ppb), ozone (O3, ppb), and particulate matter with diameter <10 μm (PM10, mg/m3) and 2.5 μm (PM2.5, mg/m3). “This study is unique in that it looks at another modifiable risk factor, besides smoking, that can impact lung cancer survival after diagnosis. The California Cancer Registry data provided a large, population-based sample of all lung cancer cases diagnosed in California over the last 20 years, minimizing the biases often encountered in other types of study designs,” said Dr. Eckel.

In general, the stage of cancer at diagnosis is a major determinant of survival, with patients diagnosed with earlier stage cancer living longer. As expected, the impacts of air pollution on survival were most evident in patients diagnosed at an early stage, when their cancer was localized to only their lungs. The median survival in patients with localized cancer at diagnosis living in areas with higher levels of fine particulate matter (PM2.5) was only 2.4 years as compared to 5.7 years in patients living in areas with lower levels of PM2.5. Patients whose cancer had spread to other parts of their bodies had shorter survival times overall and showed little difference in survival time whether they had high or low exposures to air pollution. These patterns of association persisted even after adjusting for numerous socio-demographic characteristics and type of cancer treatment.

The study’s findings are intriguing, but additional research is needed to determine the causality of the association between air pollution and lung cancer survival rates. Even so, these findings suggest that newly diagnosed lung cancer patients might want to consider taking precautions to reduce their own exposures to air pollution. As we continue to see increased emphasis on lung cancer screening, we will see more and more patients diagnosed with lung cancer at early stages and these are the patients that could potentially benefit the most from reduced air pollution exposures.

What can lung cancer patients with a locally diagnosed cancer do to take action that may effectively extend their survival times? Dr. Frank Gilliland, senior investigator on the study said, “In the short-term, common-sense precautions to reduce personal exposure to air pollution exposures include avoidance of places and times with high air pollution levels and using indoor home filtration systems. In the long-term, air quality standards should be evaluated to consider whether they are adequately protecting human health.”

The article, “Air pollution affects lung cancer survival time” by Sandrah P Eckel, Myles Cockburn, Yu-Hsiang Shu, Huiyu Deng, Frederick W Lurmann, Lihua Liu, and Frank D Gilliland. (http://dx.doi.org/10.1136/thoraxjnl-2015-207927) appears in Thorax, Published Online First (August 4, 2016)

Related links: 
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Editorial by Dr. Jamie E. Hart, Harvard
Podcast interview with Dr. Hart

This work was supported by the Southern California Environmental Health Sciences Center (grant 5P30ES007048) funded by the National Institute of Environmental Health Sciences; the Hastings Foundation; the National Cancer Institute’s Surveillance, Epidemiology and End Results Program under contract HHSN261201000140C awarded to the Cancer Prevention Institute of California, contract HHSN261201000035C awarded to the University of Southern California and contract HHSN261201000034C awarded to the Public Health Institute; and the Centers for Disease Control and Prevention’s National Program of Cancer Registries, under agreement U58DP003862-01 awarded to the California Department of Public Health.

 

Common genetic variation safeguards children from asthma

Genetic protection for lung inflammation vanishes when children constantly breathe in high-traffic pollution

by Zen Voung, USC Media Relations
Link to original article on USC News

Too much residential traffic removes the protective effect a specific gene has on lowering asthma risk, according to a new USC study.

Children could have zero, one or two copies of a common gene variant. Continue reading “Common genetic variation safeguards children from asthma”

USC News: USC, UCLA to develop children’s asthma prediction app

Technology will help young people maximize their health and reduce the burden of the incurable condition

by Zen Voung, USC Media Relations
Link to original article on USC News

USC and UCLA scientists are working on a smartphone app and cloud services platform that will predict the probability of a child’s future asthma attack and provide personalized risk management advice.

The smartphone is a personalized approach that evaluates potential real-time environmental triggers. (Graphic/Alex Bui)

Frank Gilliland, professor of preventive medicine at the Keck School of Medicine of USC, said the integrative Biomedical Real-Time Health Evaluation (BREATHE) platform he and colleagues are developing is a potentially revolutionary approach to managing asthma, one of the most common chronic childhood diseases.

“We think this is the future for asthma care,” said Gilliland, co-principal investigator of the project. “We will use real-time, high-volume information about physiology, symptoms, medication use and environmental exposures. This ‘big data’ will help physicians manage patients better and prevent exacerbations. It is a personalized medicine approach that evaluates potential real-time environmental triggers, genetics and a child’s asthma attack

Data crunch
USC and UCLA researchers will build a platform that will crunch data from children’s wearable devices, smartphones and individual electronic health records as well as real-time reports on weather conditions, air quality, pollen and allergy forecasts, and other “asthma triggers.” The algorithm will supply contextual information in a secure, cloud-based system.

The National Institute of Biomedical Imaging and Bioengineering awarded a $5.25 million grant to co-principal investigators Gilliland and Jose-Luis Ambite, a research assistant professor in the Department of Computer Science at the USC Viterbi School of Engineering. The agency also awarded UCLA a $6 million grant, of which $1.85 million is expected to be subcontracted to USC. The money in both grants will be spread across four years of research and development.

About 6.8 million children in the United States have asthma, according to the Centers for Disease Control and Prevention. The currently incurable respiratory condition cost the United States about $56 billion in medical costs, lost school and work days in 2007.

“Asthma weighs heavily on the nation in terms of public health, medical costs and quality of life,” said Alex Bui, also a principal investigator in this study and professor of radiological sciences at the David Geffen School of Medicine at UCLA. “One of the biggest challenges will be making the smart device user-friendly for young children. Kids like intuitive interfaces with bright colors, simple language, big text and quirky noises. We’re having fun exploring how to build those facets into our design.”

Take a breath
Researchers will test the platform on 8- to 12-year-old children with asthma. The algorithm scientists are developing will analyze data from the landmark USC Children’s Health Study, a litany of contextual data from environmental sensors and a history of previous asthma attacks. When exacerbating conditions arise again, the asthma app may remind a child or caregiver to bring an inhaler or medicine to ward off a future asthma attack.

“We will use technology to help people maximize their health and reduce the burden of childhood asthma,” said Gilliland, director of USC’s Division of Environmental Health. “Privacy is critical. The data has to be encrypted and secure so people could be assured their data will be confidential.”

The smartphone is a personalized approach that evaluates potential real-time environmental triggers. (Graphic/Alex Bui)